Recombinant Cadherin-6 Monoclonal Antibody
Product Specifications
Background
Cadherin-6, also known as kidney cadherin (K-Cadherin, CDH6) is a type II classical cadherin. While it was reported to have a tumor suppressor function in cholangiocarcinoma, cadherin-6 expression was shown to be a marker of epithelial mesenchymal transition, and positively correlated with stage and metastasis of papillary thyroid carcinoma. In related studies, cadherin-6 was shown to interact with GABARAP and related proteins to restrain autophagy, thereby promoting metastatic behavior. Cadherin-6 has since been proposed as an antibody-drug conjugate target for the treatment of ovarian and renal cancers.
Abbreviation
Cadherin-6
UniProt
P55285
Host
Rabbit
Reactivity
Human
Immunogen
Peptide. This information is proprietary to PTMab.
Target
CAD; Cadherin 6 type; CADH; CAD6; CADH6; Cadherin 6; Cadherin 6 type 2; Cadherin 6 type 2 K cadherin (fetal kidney) ; Cadherin fetal kidney; Cadherin6; Cadherin-6; CDH 6; KCAD; K-Cadherin; Kidney Cadherin; CDH6
Clonality
Monoclonal,Recombinant
Clone
A728
Conjugation
Unconjugated
Applications
WB
Field of Research
Signal Transduction; Cancer
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:1000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
88 kDa
Observed Molecular Weight
130 kDa
Isotype
IgG, κ
Available Sizes
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