Recombinant CD137 Monoclonal Antibody
Product Specifications
Background
TNFRSF9 is a member of the tumor necrosis factor receptor superfamily. It is also called 4-1BB or CD137. 4-1BB/CD137/TNFRSF9 is expressed in activated CD4+ and CD8+ T cells, natural killer cells and dendritic cells. The ligand 4-1BBL/CD137L/TNFSF9 on antigen presenting cells binds to 4-1BB/CD137/TNFRSF9 and costimulates the activation of T cells. The binding of agonistic antibodies to 4 1BB/CD137/TNFRSF9 also leads to costimulation for T cell activation. Studies have shown the effectiveness of targeting 4 1BB/CD137/TNFRSF9 by its agonistic antibodies in cancer immunotherapy.
Abbreviation
CD137
UniProt
P20334
Host
Rabbit
Reactivity
Mouse
Immunogen
Peptide. This information is proprietary to PTMab.
Target
TNFRSF; Cd137; Ila; Ly63; Tnfrsf9;4-1BB; TNFRSF9
Clonality
Monoclonal,Recombinant
Clone
A726
Conjugation
Unconjugated
Applications
WB
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:1000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
34 kDa
Observed Molecular Weight
34 kDa
Isotype
IgG, κ
Available Sizes
Frequently Asked Questions
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