Recombinant RON Monoclonal Antibody
Product Specifications
Background
Ron is a member of the Met protooncogene family of receptor tyrosine kinases, which also includes Stk, c-Met, and c-Sea. The functional Ron is a heterodimer composed of a 40 kDa α chain and a 150 kDa β chain. Ron is initially synthesized in the cells as a single-chain, pro Ron precursor that is cleaved into the two active chains. The α chain is completely extracellular, whereas the β chain traverses the cell membrane and contains the intracellular tyrosine kinase and regulatory elements. Ron mediates multiple signaling cascades that involve cell motility, adhesion, proliferation, and apoptosis.The signaling pathways activated downstream of Ron include the ras/mitogen-activated protein kinase (MAPK), phosphatidyl inositol-3 kinase (PI3K) /Akt, and focal adhesion kinase (FAK) pathways. Ron activation can also significantly increase c-Src activity, a signaling intermediate involved in cell cycle progression, motility, angiogenesis and survival. The function of Ron has been shown to be important for embryological development as well as implicated in the progression and metastasis of tumors.
Abbreviation
RON
UniProt
Q04912
Host
Rabbit
Reactivity
Human
Immunogen
Peptide. This information is proprietary to PTMab.
Target
PTK; CDw; CD136; CDw136; PTK8; RON; MST1R; MSP-R; RON; CDw136
Clonality
Monoclonal,Recombinant
Clone
A721
Conjugation
Unconjugated
Applications
WB
Field of Research
Cell Biology; Signal Transduction
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:2000-1:5000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
152 kDa
Observed Molecular Weight
150,175 kDa
Isotype
IgG, κ
Available Sizes
Frequently Asked Questions
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