Recombinant COUP-TFII Monoclonal Antibody

Chicken ovalbumin upstream promoter transcription factor (COUP-TF) belongs to the NR2 subfamily of the nuclear hormone receptor family. COUP-TFI and COUP-TFII are two of the well-characterized members in the NR2 subfamily. These two members are highly conserved in their two zinc-finger DNA binding domains (DBD) and the ligand binding domain (LBD), and function as repressors or activators of downstream target genes to regulate different biological processes. COUP-TFI and II bind to 5'-AGGTCA-3' motif palindromes, either directly or indirectly, through heterodimer formation with other proteins (e.g. RXRs) to regulate downstream target gene expression. COUP-TFI is involved in neuronal development, tissue patterning, and differentiation. COUP-TFII has been shown to be involved in angiogenesis, glucose homeostasis, and mesenchymal cell commitment.

SVP; COT; CHTD; NF-E; COUP transcription factor; Apolipoprotein AI regulatory protein; Apolipoprotein A-I regulatory protein; Nuclear receptor subfamily 2 group F member; TFCOUP; COUP TF; COUP-TF; ARP; NR2F2; ARP1; CHTD4; COUPTFB; COUPTFII; NF-E3; SVP40; TFCOUP2; Apolipoprotein AI regulatory protein 1; Apolipoprotein A-I regulatory protein 1; ARP-1; COT2; COUP TF2; COUP transcription factor 2; COUP transcription factor II; COUP-TF II; COUP-TF2; NR2F1; Nuclear receptor subfamily 2 group F member 2