Recombinant Glutamate receptor 3 Monoclonal Antibody

AMPA receptors (AMPARs) are comprised of four subunits (GluR 1-4) that assemble as homo- or hetero-tetramers and mediate the majority of fast excitatory transmissions in the CNS. AMPARs are implicated in synapse formation, stabilization and plasticity. Glutamate receptor 3 (GluR3) knockout mice exhibited normal basal synaptic transmission and long-term depression (LTD) but enhanced long-term potentiation (LTP) . In contrast, GluR 2/3 double knockout mice are impaired in basal synaptic transmission. Aberrant GluR3 expression or activity is implicated in a number of diseases, including autoimmune epilepsy, X-linked mental retardation, Rett's syndrome, amyotrophic lateral sclerosis and Alzheimer disease.

MRX; GRIA; GLUR; GluA; GLUR-K; GRIA3; GLUR-C; GLUR-K3; GLUR3; GLURC; GluA3; MRX94; AMPA 3; AMPA selective glutamate receptor 3; AMPA-selective glutamate receptor 3; dJ1171F9.1; GLUK3; GluR 3; GLUR C; GLUR K3; GluR-3; Glutamate ionotropic receptor AMPA type subunit 3; Glutamate receptor; Glutamate receptor 3; Glutamate receptor C; Glutamate receptor ionotrophic AMPA 3; Glutamate receptor ionotropic; Glutamate receptor subunit 3; GRIA 3; Ionotrophic Glutamate Receptor; ionotropic