Recombinant beta III Tubulin Monoclonal Antibody

Product Specifications

Background

Beta III Tubulin (TUBB3) is one of six β-tubulin isoforms and is expressed highly during fetal and postnatal development (axon guidance and maturation) . Its expression levels decrease in the adult central nervous system (CNS) but remain high in the peripheral nervous system (PNS) . Microtubules enriched in β3-tubulin are more dynamic than those composed of other β-tubulin isoforms. Research studies have shown that mutations in the β3-tubulin gene TUBB3 cause ocular motility defects and other nervous system disorders. Furthermore, β3-tubulin is present in neoplastic but not in normal differentiated glial cells. Thus, β3-tubulin is a great neuronal marker.

Abbreviation

Beta III Tubulin

UniProt

Q13509

Host

Rabbit

Reactivity

Human; Rat; Mouse

Immunogen

Recombinant human beta III Tubulin fragment

Target

FEOM; beta; CFEOM; CDCBM; CDCBM1; CFEOM3; CFEOM3A; FEOM3; TUBB4; beta-4; beta Tubulin III; TUBB3; beta 3 tubulin; M (beta) 3; M (beta) 6; MC1R; Neuron specific beta III Tubulin; Neuron-specific class III beta-tubulin; QccE-11995; QccE-15186; TBB3; Tubb 3; Tubulin beta 3; Tubulin beta 3 chain; Tubulin beta 4; Tubulin beta III; Tubulin beta-3 chain; Tubulin beta-4 chain; Tubulin beta-III