Recombinant CHD4 Monoclonal Antibody
Product Specifications
Background
Chromodomain helicase DNA-binding protein 4 (CHD4) is an ATP dependent chromatin remodeler and a major subunit of the repressive NuRD complex. This complex plays key roles in transcriptional regulation and reorganization and maintenance of chromatin structure, as it targets pericentromeric heterochromatin and has recently been implicated in DNA damage repair, being rapidly recruited to DNA double strand breaks. CHD4 is a novel BRIT1 binding partner that regulates the HR repair process, which is a critical pathway of repairing DNA double strand breaks and plays an essential role in maintaining genomic integrity. The calculated molecular weight of CHD4 is 218 kDa, but modified CHD4 is about 250-280 kDa.
Abbreviation
CHD4
UniProt
Q14839
Host
Rabbit
Reactivity
Human; Rat; Mouse
Immunogen
Recombinant human CHD4 fragment
Target
CHD; CHD4; CHD-4; Mi-2b; Mi2-BETA; SIHIWES
Clonality
Monoclonal,Recombinant
Clone
A649
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Immunology; Epigenetics and Nuclear Signaling
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:1000-3000; IHC 1:50-100
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
218 kDa
Observed Molecular Weight
280 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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