Recombinant Rab8A Monoclonal Antibody

The Rab8 GTPase is a member of the Ras superfamily that functions in protein transport and membrane restructuring. RAB8 has two isoforms, RAB8A and RAB8B, that share 40% amino acid identity in the C-terminal variable region. RAB8 activity is regulated by specific guanine nucleotide exchange factors (GEFs), that mediate GTP loading, and GTPase activating proteins (GAPs) that convert them into the inactive GDP-bound form. RAB8 participates in recycling of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors to the dendritic spine surface as well as in the intracellular transport of the metabotropic glutamate receptor type 1 in neuronal cells. Rab8 is activated at the base of the cilium by its guanine nucleotide exchanger Rabin8.

RAB; RAB8A; MEL; RAB8; AA409338; Mel transforming oncogene; Mel transforming oncogene (derived from cell line NK14) ; Mel transforming oncogene (derived from cell line NK14) RAB8 homolog; Mel transforming oncogene (RAB8 homolog) ; MGC124948; Oncogene c mel; Oncogene c-mel; RAB8A member RAS oncogene family; Ras associated protein RAB8; Ras related protein Rab 8A; Ras-related protein Rab-8A