Recombinant HOXB13 Monoclonal Antibody

HOXB13 is a member of the HOXB cluster which, along with the HOXA, HOXC, and HOXD clusters, governs embryonic patterning along the cranio-caudal axis. HOXB13 plays a key role in the development of the ventral prostate, where it is expressed highly from the embryonic stage through adulthood. Research studies have shown that both overexpression and RNA interference can inhibit the growth of prostate cancer cells. HOXB13 can function as a tumor suppressor by negatively regulating growth through repression of TCF4 and androgen receptor (AR) signaling. However, HOXB13 has also been shown to be overexpressed in more invasive prostate cancers, breast and ovarian cancers, and hepatocellular carcinomas. A common germline mutation G84E in the HOXB13 protein has recently been found to be associated with significant increased risk of prostate cancer. Currently, HOXB13 is being evaluated as a marker for metastatic lesions of prostate origin.

HXB; Homeobox B; Homeo box B; Homeobox protein HoxB; Homeobox protein Hox B; Homeobox protein Hox-B; HOX B; HOXB13; PSGD; Homeo box B13; Homeobox B13; Homeobox protein Hox B13; Homeobox protein HoxB13; Homeobox protein Hox-B13; HOX B13; HOXB 13; HXB13; PSGD protein