Recombinant IL-1RA Monoclonal Antibody

The founding members of the interleukin-1 (IL-1) superfamily include pro-inflammatory cytokines IL-1α, IL-1β and IL-1 receptor antagonist (IL-1RA) . At least six similar proteins have been recently identified, including a homolog of IL-1RA (IL1F5) . IL-1a, IL-1b and IL-1RA are mainly expressed in macrophages, monocytes, and dendritic cells. IL-1RA acts as an anti-inflammatory cytokine, binding the IL-1 receptor to limit the response to inflammation. Because it plays a key role in regulating the inflammatory response, recombinant IL-1RA is a therapeutic agent used in the treatment of diseases such as rheumatoid arthritis. Alternatively, mutation of the corresponding IL-1RA gene may be associated with susceptibility to the development of specific cancers.

IL1F; MVCD; IL1RN; DIRA; ICIL-1RA; IL-1RN; IL-1ra; IL-1ra3; IL1F3; IL1RA; IRAP; MVCD4; Anakinra; IL1 inhibitor; Interleukin-1 receptor antagonist protein; F630041P17Rik; ICIL 1RA; ICIL1RA; IL1RN (IL1F3) ; Interleukin 1 receptor antagonist; Intracellular IL 1 receptor antagonist type II; Intracellular interleukin 1 receptor antagonist (icIL 1ra) ; MGC10430; Type II interleukin 1 receptor antagonist