Recombinant TGF beta 1 Monoclonal Antibody

Transforming growth factor-β (TGF-β) superfamily members are critical regulators of cell proliferation and differentiation, developmental patterning and morphogenesis, and disease pathogenesis. TGF-β elicits signaling through three cell surface receptors: type I (RI), type II (RII), and type III (RIII) . Type I and type II receptors are serine/threonine kinases that form a heteromeric complex. In response to ligand binding, the type II receptors form a stable complex with the type I receptors allowing phosphorylation and activation of type I receptor kinases. The type III receptor, also known as betaglycan, is a transmembrane proteoglycan with a large extracellular domain that binds TGF-β with high affinity but lacks a cytoplasmic signaling domain. Expression of the type III receptor can regulate TGF-β signaling through presentation of the ligand to the signaling complex. The only known direct TGF-β signaling effectors are the Smad family proteins, which transduce signals from the cell surface directly to the nucleus to regulate target gene transcription.

DPD; Transforming growth factor beta; TGF-B; TGFB1; CED; DPD1; LAP; TGFB; TGFbeta; TGF-β; Cartilage-inducing factor; Differentiation inhibiting factor; IBDIMDE; TGF-B1; TGF-beta 1; TGF-beta-1; TGF-β1; Transforming growth factor beta-1 proprotein; Latency-associated peptide; Transforming growth factor beta-1; beta 1; Prepro transforming growth factor beta 1; TGF beta; TGF beta 1; TGF beta 1 protein; Tgfb-1; TGF-beta 1 protein; TGFbeta1; TGF-beta1; TGF-beta-5; transforming growth factor; Transforming Growth Factor b1; Transforming Growth Factor beta 1; Transforming growth factor beta 1a; Transforming Growth Factor-1