Recombinant Gelsolin Monoclonal Antibody
Product Specifications
Background
Gelsolin also named as actin-depolymerizing factor, ADF, AGEL or Brevin, is an 83 kDa protein that shares structural and functional homology to villin and adseverin/scinderin. Gelsolin plays an important role in actin filament assembly by capping and severing actin proteins in a Ca2+-dependent manner. Gelsolin is important for cellular events (e.g., membrane ruffling, chemotaxis, ciliogenesis) that require cytoskeletal remodeling. Accordingly, cells from gelsolin knockout mice exhibit motility defects, including a failure to ruffle in response to growth factor stimulation. In humans, defects in gelsolin have been linked to amyloidosis type 5 (AMYL5), a hereditary disease characterized by cranial neuropathy, which appears to result from gelsolin amyloid deposition.
Abbreviation
Gelsolin
UniProt
P06396
Host
Rabbit
Reactivity
Human; Rat; Mouse
Immunogen
Recombinant human Gelsolin fragment
Target
DKFZp313L; GSN; ADF; AGEL; gelsolin; Actin depolymerizing factor; DKFZp313L0718; Brevin; GELS; Actin-depolymerizing factor; Actin-depolymerizing factor; ADF; AGEL; Brevin; GELS; GSN
Clonality
Monoclonal,Recombinant
Clone
A612
Conjugation
Unconjugated
Applications
WB
Field of Research
Signal Transduction
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:100-1:1000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
85 kDa
Observed Molecular Weight
82 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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