Recombinant PLCG2 Monoclonal Antibody
Product Specifications
Background
Phospholipase C-gamma2 (PLCG2) is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor.IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome.
Abbreviation
PLCG2
UniProt
P16885
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant human PLCG2 fragment
Target
PLCG; FCAS; PLC-gamma; PLCG2; APLAID; FCAS3; PLC-IV; PLC-gamma-2; phospholipase C gamma 2
Clonality
Monoclonal,Recombinant
Clone
A609
Conjugation
Unconjugated
Applications
WB
Field of Research
Signal Transduction; Cardiovascular; Metabolism
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:500-1:1000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
148 kDa
Observed Molecular Weight
148 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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