Recombinant Caspase-7 Monoclonal Antibody
Product Specifications
Background
Caspase-7, also named as CMH-1, Mch3 and ICE-LAP3, has been identified as a major contributor to the execution of apoptosis. Caspase-7, like caspase-3, is an effector caspase that is responsible for cleaving downstream substrates such as ADP-ribose polymerase and PARP. During apoptosis, caspase-7 is activated through proteolytic processing by upstream caspases at Asp23, Asp198, and Asp206 to produce the mature subunits. Similar to caspase-2 and -3, caspase-7 preferentially cleaves substrates following the recognition sequence DEVD.
Abbreviation
Caspase-7
UniProt
P97864
Host
Rabbit
Reactivity
Rat; Mouse
Immunogen
Recombinant human Caspase-7 fragment
Target
Mch; Lice; CASP; Lice2; Mch3; Casp7; CASP-7; Caspase 7; CMH-1; ICE-LAP3
Clonality
Monoclonal,Recombinant
Clone
A586
Conjugation
Unconjugated
Applications
WB; IHC
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:500-1:1000; IHC 1:200-1:1000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
34 kDa
Observed Molecular Weight
34 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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