Recombinant HER4/ErbB4 Monoclonal Antibody

HER4/ErbB4, like other receptor tyrosine kinase family members, has four ectodomains, a single transmembrane domain and a cytoplasmic tail containing the active tyrosine kinase domain. By binding to neuregulins and/or EGF family ligands, ErbB4 forms either a homodimer or heterodimer with other ErbB family members, which results in receptor activation and signaling. ErbB4 is ubiquitously expressed with the highest expression occurring in brain and heart. The expression of ErbB4 in breast cancer, pediatric brain cancer and other types of carcinomas has been reported in research studies suggesting that ErbB4 expression is involved in both normal tissue development and carcinogenesis.

ALS; HER; ERBB; Proto-oncogene-like protein c-ErbB; Receptor tyrosine-protein kinase erbB; Tyrosine kinase-type cell surface receptor HER; p180erbB; HER4/ErbB; ALS19; HER4; p180erbB4; ERBB4; HER4/ErbB4; Proto-oncogene-like protein c-ErbB-4; Receptor tyrosine-protein kinase erbB-4; Tyrosine kinase-type cell surface receptor HER4;4ICD; Avian erythroblastic leukemia viral oncogene homolog 4; Avian erythroblastic leukemia viral v erb b2 oncogene homolog 4; E4ICD; EC 2.7.10.1; ERBB4 intracellular domain; HER 4; human epidermal growth factor receptor 4; Mer4; MGC138404; Oncogene ERBB4; Receptor protein tyrosine kinase erbB 4 precursor; Receptor tyrosine protein kinase erbB 4; s80HER4; Tyrosine kinase type cell surface receptor HER4; v erb a avian erythroblastic leukemia viral oncogene homolog like 4; v erb a erythroblastic leukemia viral oncogene homolog 4; Verba avian erythroblastic leukemia viral oncogene homolog like 4; Verba erythroblastic leukemia viral oncogene homolog 4; v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) ; VERBB2; V-ERB-B2 avian erythroblastic leukemia viral oncogene homolog 4