Recombinant Aconitase 1/ACO1 Monoclonal Antibody

Aconitase 1 is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA.

HEL; IRP; ACO; IREB; ACO1; ACONS; HEL60; IREB1; IREBP; IREBP1; IRP1; ACO 1; ACOC; Aconitase; Aconitase 1 soluble; Aconitase1; Aconitate hydratase; Citrate hydro lyase; Citrate hydro-lyase; Cytoplasmic aconitate hydratase; Ferritin repressor protein; IRE BP 1; IREB 1; IRE-BP 1; Iron regulatory protein 1; Iron responsive element binding protein 1; Iron-responsive element-binding protein 1; IRP 1; OTTHUMP00000045233