Recombinant CX3CR1 Monoclonal Antibody
Product Specifications
Background
CX3CR1 is a G-protein-coupled seven-transmembrane chemokine receptor, also known as GPR13 or V28. It is expressed on microglia, astrocytes, NK cells, monocytes/macrophages, and a subpopulation of T cells. CX3CR1 is the receptor for fractalkine (CX3CL1) and mediates both its adhesive and migratory functions. It also acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro), and some variations in the gene of CX3CR1 lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Defects in CX3CR1 are a cause of susceptibility to age-related macular degeneration type 12 (ARMD12) .
Abbreviation
CX3CR1
UniProt
P49238
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant human CX3CR1 fragment
Target
GPR; CCRL; GPRV; CX3CR; CMKDR; CMKBRL; CX3CR1; CCRL1; CMKBRL1; CMKDR1; GPR13; GPRV28; V28; Beta chemokine receptor-like 1; CMK-BRL1; CMK-BRL-1; CX3C chemokine receptor 1; C-X3-C CKR-1; C-X3-C motif chemokine receptor 1; fractalkine receptor; G-protein coupled receptor 13
Clonality
Monoclonal,Recombinant
Clone
A576
Conjugation
Unconjugated
Applications
WB
Field of Research
Microbiology; Tags & Cell Markers; Immunology; Neuroscience; Cancer
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:500-1:1000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
40 kDa
Observed Molecular Weight
50 kDa
Isotype
IgG, κ
Available Sizes
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