Recombinant ATF1 Monoclonal Antibody
Product Specifications
Background
ATF-1 is a bZIP transcription factor that is a member of the cyclic AMP (cAMP) -response element-binding protein (CREB) family. Like other members of the CREB family, ATF-1 mediates signals from numerous physiological stimuli and activates target genes through cAMP-response elements, resulting in the regulation of a broad array of cellular responses. ATF-1 can be phosphorylated at Ser63 by protein kinase A (PKA), calmodulin-dependent protein kinase (CaMK), and cyclin-dependent kinase 3 (CDK3), which recruits CBP/p300 and enhances transcriptional activity. ATF-1 expression levels have been found to be elevated in lymphomas and metastatic melanoma cells, where it contributes to tumor growth.
Abbreviation
ATF1
UniProt
P81269
Host
Rabbit
Reactivity
Human; Rat; Mouse
Immunogen
Recombinant human ATF1 fragment
Target
ATF; Atf1
Clonality
Monoclonal,Recombinant
Clone
A562
Conjugation
Unconjugated
Applications
WB; IHC; IF; FCM
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:500-1:1000; IHC 1:100-1:1000; IF 1:50; FCM 1:50-1:100
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
29 kDa
Observed Molecular Weight
35 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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