Recombinant HSD17B1 Monoclonal Antibody

HSD17B1 is a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. HSD17B1 catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. HSD17B1 is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate.

HSD; EDHB; HSD17B; SDR28C; HSD17B1;17-beta-HSD;20-alpha-HSD; E2DH; EDH17B2; EDHB17; HSD17; SDR28C1; E17KSR; EDH17B1;17 beta HSD 1;17 beta hydroxysteroid dehydrogenase type 1;17-beta-HSD 1;17-beta-hydroxysteroid dehydrogenase type 1;20 alpha-hydroxysteroid dehydrogenase; DHB1; Estradiol 17 beta dehydrogenase 1; Estradiol 17-beta-dehydrogenase 1; Hydroxysteroid (17 beta) dehydrogenase 1; member 1; MGC13814; Placental 17 beta hydroxysteroid dehydrogenase; Placental 17-beta-hydroxysteroid dehydrogenase; Short chain dehydrogenase/reductase family 28CE