Recombinant Ret Monoclonal Antibody
Product Specifications
Background
The Ret is a receptor tyrosine kinase that functions as a multicomponent receptor complex in conjunction with other membrane-bound, ligand-binding GDNF family receptors. Ligands that bind the Ret receptor include the glial cell line-derived neurotrophic factor (GDNF) and its congeners neurturin, persephin, and artemin. Research studies have shown that alterations in the corresponding RET gene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma, and a congenital developmental disorder known as Hirschsprung’s disease.
Abbreviation
Ret
UniProt
P07949
Host
Rabbit
Reactivity
Human; Mouse
Immunogen
Recombinant human Ret fragment
Target
MTC; CDHF; CDHR; HSCR; Cadherin family member; RET-ELE; RET; CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET-ELE1; RET51; Cadherin family member 12; Proto-oncogene c-Ret; Proto-oncogene tyrosine-protein kinase receptor Ret; Proto-oncogene tyrosine-protein kinase receptor Ret; Cadherin family member 12; Proto-oncogene c-Ret
Clonality
Monoclonal,Recombinant
Clone
A548
Conjugation
Unconjugated
Applications
WB
Field of Research
Signal Transduction; Cancer
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:1000-1:5000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
124 kDa
Observed Molecular Weight
175 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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