Recombinant CD74 Monoclonal Antibody

CD74, also known as the MHC Class II-associated invariant chain (Ii), is a type II transmembrane glycoprotein that plays a critical role in the antigen presentation process as a chaperone of MHC Class II proteins. It is expressed at high levels on B cells and to a lesser extent on numerous antigen presenting cell (APC) types including dendritic cells, Langerhans cells, monocytes, and macrophages as well as non-traditional APCs such as epithelial cells. CD74 was initially identified for its ability to regulate the folding and intracellular trafficking of newly synthesized MHC Class II molecules. Following expression, CD74 self-assembles as a trimer that serves as a scaffold for the assembly of MHC Class II molecules. Through this interaction, CD74 blocks the peptide binding cleft of MHC Class II molecules and prevents their premature association with endogenous polypeptides. Binding to CD74 also facilitates the translocation of MHC Class II molecules from the endoplasmic reticulum to the endocytic compartments during antigen presentation.

HLA class II histocompatibility antigen gamma chain; HLADG; Ia antigen-associated invariant chain; Ia-GAMMA II; Ii; p33; CD74 HLA-DR antigens-associated invariant chain; DHLAG; CD74; invariant chain; CD 74; CD74 antigen; CD74 antigen (invariant polypeptide of major histocompatibility complex; CD74 molecule; class II antigen-associated) ; class II invariant chain; CLIP; Gamma chain of class II antigens; HG2A; HLA DR antigens associated invariant chain; HLA DR gamma; HLADR antigens associated invariant chain; HLA-DR antigens-associated invariant chain; HLA-DR-gamma; Ia antigen associated invariant chain; Ia associated invariant chain; Ia gamma; Ia-GAMMA; Invariant polypeptide of major histocompatibility complex class II antigen associated; la-gamma; major histocompatibility complex; Major histocompatibility complex class II invariant chain; MHC HLA DR gamma chain; MHC HLA-DR gamma chain; p35; Protein 41; CD74; DHLAG; HLA class II histocompatibility antigen gamma chain; HLADG; Ia antigen-associated invariant chain; p33; CD 14; CD_antigen=CD14; CD14; CD14 antigen; CD14 molecule; LPS-R; Mo2; Monocyte differentiation antigen CD14; Monocyte differentiation antigen CD14 urinary form; membrane-bound form; Myeloid cell specific leucine rich glycoprotein; Myeloid cell-specific leucine-rich glycoprotein