Recombinant RING1B Monoclonal Antibody
Product Specifications
Background
RING1B is a E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It may be involved in the initiation of both imprinted and random X inactivation. It E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4.
Abbreviation
RING1B
UniProt
Q9CQJ4
Host
Rabbit
Reactivity
Human; Rat; Mouse
Immunogen
Recombinant human RING1B fragment
Target
RNF; DinG; Ring1b; Rnf2
Clonality
Monoclonal,Recombinant
Clone
A531
Conjugation
Unconjugated
Applications
WB; IHC; IF; FCM
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:500-1:1000; IHC 1:200-1:1000; IF 1:50; FCM 1:50-1:100
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
38 kDa
Observed Molecular Weight
38 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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