Recombinant CBX4 Monoclonal Antibody
Product Specifications
Background
CBX4 is a component of the PRC1 complex, which together with Ring1 strongly enhances the E3 ubiquitin ligase activity of the Ring2 catalytic subunit. CBX4 itself is a SUMO E3 ligase, and its function influences EMT, DNA damage response, tumor angiogenesis, and self-renewal. E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. It is involved in the SUMOylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression.
Abbreviation
CBX4
UniProt
O00257
Host
Rabbit
Reactivity
Human; Rat; Mouse
Immunogen
Recombinant human CBX4 fragment
Target
Cbx; CBX4
Clonality
Monoclonal,Recombinant
Clone
A527
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Epigenetics and Nuclear Signaling
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB (human) 1:500-1:1000; WB (rat) 1:1000-1:5000; IHC 1:200-1:1000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
61 kDa
Observed Molecular Weight
61 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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