Recombinant Thymidylate Synthase Monoclonal Antibody
Product Specifications
Background
Thymidylate synthase is a homodimer composed of two 30 kDa subunits, which catalyze the methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), an essential step in the formation of thymine nucleotides. Thymidylate synthase is an intracellular enzyme that provides the sole de novo source of thymidylate, making it a required enzyme in DNA biosynthesis with activity highest in proliferating cells. Being the exclusive source of dTMP, investigators have concluded that TS is also an important target for anticancer agents such as 5-fluorouracil (5-FU) . 5-FU acts as a TS inhibitor and is active against solid tumors such as colon, breast, head, and neck.
Abbreviation
Thymidylate Synthase
UniProt
P04818
Host
Rabbit
Reactivity
Human; Rat; Mouse
Immunogen
Recombinant human Thymidylate Synthase fragment
Target
HST; OK/SW-cl; TYMS; HST422; TMS; TS; thymidylate synthase; OK/SW-cl.29; HST422; thymidylate synthase; TMS; thymidylate synthetase
Clonality
Monoclonal,Recombinant
Clone
A524
Conjugation
Unconjugated
Applications
WB; IF; FCM
Field of Research
Epigenetics and Nuclear Signaling; Metabolism
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000; IF 1:50; FCM 1:50-1:100
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
36 kDa
Observed Molecular Weight
36 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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