Recombinant MTAP Monoclonal Antibody
Product Specifications
Background
MTAP is an enzyme essential for the salvage pathway for both adenine and methionine synthesis. MTAP catalyzes the cleavage of 5’-methylthioadenosine into adenine and 5-methylthio-D-ribose-1-phosphate. Adenine is then used to generate AMP whereas 5-methylthio-D-ribose-1-phosphate is converted into methionine. MTAP is expressed in all normal cells and tissues, although frequently lost in different human tumors including pancreatic adenocarcinoma, neuroendocrine tumors, non-small cell lung carcinoma and breast carcinoma, thereby implicating its potential function as a tumor suppressor.
Abbreviation
MTAP
UniProt
Q13126
Host
Rabbit
Reactivity
Human; Mouse
Immunogen
Recombinant human MTAP fragment
Target
HEL; MTAP; BDMF; DMSFH; DMSMFH; HEL-249; LGMBF; MSAP; c86fus;5' methylthioadenosine phosphorylase;5''-methylthioadenosine phosphorylase; Epididymis luminal protein 249; HEL 249; MeSAdo phosphorylase; Methylthioadenosine phosphorylase; MTA phosphorylase; MTAPase; S methyl 5 thioadenosine phosphorylase; S methyl 5' thioadenosine phosphorylase; S-methyl-5''-thioadenosine phosphorylase
Clonality
Monoclonal,Recombinant
Clone
A519
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Signal Transduction; Metabolism
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:1000-1:3000; IHC 1:50-1:100
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
31 kDa
Observed Molecular Weight
31 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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