Recombinant MTAP Monoclonal Antibody

MTAP is an enzyme essential for the salvage pathway for both adenine and methionine synthesis. MTAP catalyzes the cleavage of 5’-methylthioadenosine into adenine and 5-methylthio-D-ribose-1-phosphate. Adenine is then used to generate AMP whereas 5-methylthio-D-ribose-1-phosphate is converted into methionine. MTAP is expressed in all normal cells and tissues, although frequently lost in different human tumors including pancreatic adenocarcinoma, neuroendocrine tumors, non-small cell lung carcinoma and breast carcinoma, thereby implicating its potential function as a tumor suppressor.

HEL; MTAP; BDMF; DMSFH; DMSMFH; HEL-249; LGMBF; MSAP; c86fus;5' methylthioadenosine phosphorylase;5''-methylthioadenosine phosphorylase; Epididymis luminal protein 249; HEL 249; MeSAdo phosphorylase; Methylthioadenosine phosphorylase; MTA phosphorylase; MTAPase; S methyl 5 thioadenosine phosphorylase; S methyl 5' thioadenosine phosphorylase; S-methyl-5''-thioadenosine phosphorylase