Recombinant IKK gamma Monoclonal Antibody

IKK gamma (IKKγ) is a subunit of a high molecular weight IκB kinase (IKK) complex, which is involved in NF-κB activation. The catalysis of IκB kinase (IKK) complex is generally carried out by three tightly associated IKK subunits. IKKα and IKKβ serve as the catalytic subunits of the kinase and IKKγ serves as the regulatory subunit. Activation of IKK depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKKβ (Ser176 and Ser180 in IKKα), which causes conformational changes, resulting in kinase activation. Activation of the NF-κB pathway by the T-cell lymphotrophic virus Tax protein or by TNF-α treatment leads to IKKβ-dependent phosphorylation of human IKKγ, primarily at Ser376. In mice, mutation of the orthologous residue (Ser369) to alanine leads to enhanced IKKγ-mediated stimulation of IKKβ kinase activity.

IMD; IPD; AMCBX; IKKAP; ZC2HC; FIP; IKBKG; AMCBX1; FIP-3; FIP3; Fip3p; IKK-gamma; IKKAP1; IKKG; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9; NF-kappa-B essential modulator; FIP 3; gamma; I kappa B kinase gamma; I-kappa-B kinase subunit gamma; IkB kinase associated protein 1; IkB kinase gamma subunit; IkB kinase subunit gamma; IkB kinase-associated protein 1; Incontinentia pigmenti; Inhibitor of kappa light polypeptide gene enhancer in B cells; Inhibitor of nuclear factor kappa B kinase subunit gamma; Inhibitor of nuclear factor kappa-B kinase subunit gamma; kinase gamma; kinase of; NF kappa B essential modifier; NF kappa B essential modulator; NF-kappa-B essential modifier