Recombinant ALIX Monoclonal Antibody
Product Specifications
Background
Programmed cell death 6-interacting protein (PDCD6IP), plays an important role in the endosomal sorting complexes required for transport (ESCRT) pathway in the abscission stage of cytokinesis and apoptosis. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the protein binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. It also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this protein and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death.
Abbreviation
ALIX
UniProt
Q8WUM4
Host
Rabbit
Reactivity
Human; Rat; Mouse
Immunogen
Recombinant human ALIX fragment
Target
AIP; DRIP; KIAA; PDCD6IP; AIP1; ALIX; DRIP4; HP95; KIAA1375
Clonality
Monoclonal,Recombinant
Clone
A493
Conjugation
Unconjugated
Applications
WB; IHC; IP
Field of Research
Cell Biology; Microbiology; Signal Transduction
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:2000-1:10000; IHC 1:100-1:500; IP 1:25-1:50
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Product MSDS
https://789.bio/eb/x1OHGAY4
Calculated Molecular Weight
96 kDa
Observed Molecular Weight
90/100 kDa
Isotype
IgG, κ
Available Sizes
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