Recombinant ATG4B Monoclonal Antibody
Product Specifications
Background
ATG4B is a member of the autophagin protein family. Its cysteine protease activity is required for the cytoplasm to vacuole transport (Cvt) and autophagy. ATG4B cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy.
Abbreviation
ATG4B
UniProt
Q9Y4P1
Host
Rabbit
Reactivity
Human; Rat; Mouse
Immunogen
Recombinant human ATG4B fragment
Target
AUTL; KIAA; ATG4B; APG4B; AUTL1; cysteine protease ATG4B; KIAA0943; APG4B; AUTL1; cysteine protease ATG4B; APG4 autophagy 4 homolog B; ATG4 autophagy related 4 homolog B (S. cerevisiae) ; AUT like 1 cysteine endopeptidase; AUT-like 1 cysteine endopeptidase; Autophagin 1; Autophagin-1; Autophagy related 4B cysteine peptidase; Autophagy related cysteine endopeptidase 1; Autophagy related protein 4 homolog B; Autophagy-related cysteine endopeptidase 1; Autophagy-related protein 4 homolog B; hAPG4B; MGC1353
Clonality
Monoclonal,Recombinant
Clone
A447
Conjugation
Unconjugated
Applications
WB; IHC; FCM
Field of Research
Cancer; Cell Biology; Cardiovascular; Metabolism
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:500-1:1000; IHC 1:200-1:1000; FCM 1:50-1:100
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
44 kDa
Observed Molecular Weight
44 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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