Recombinant DNMT1 Monoclonal Antibody
Product Specifications
Background
Dnmt1 is an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities.
Abbreviation
DNMT1
UniProt
P26358
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant human Dnmt1 fragment
Target
MGC; CXXC; DNA methyltransferase; CXXC finger protein 9|DNA methyltransferase; ADCADN; AIM; CXXC9; DNMT; HSN1E; MCMT; m.HsaI; DNMT1; CXXC finger protein 9|DNA methyltransferase 1; DNA methyltransferase 1; FLJ16293; MGC104992; ADCADN; AIM; CXXC9; DNA methyltransferase 1; DNMT; HSN1E; m.HsaI; MCMT; CXXC finger protein 9; CXXC-type zinc finger protein 9; DNA (cytosine 5) methyltransferase 1; DNA (cytosine-5) -methyltransferase 1; DNA methyltransferase HsaI; DNA methyltransferase M.HsaI.; DNA MTase; DNA MTase HsaI; DNMT 1; Dnmt1o; Met1; mMmul; MommeD2
Clonality
Monoclonal,Recombinant
Clone
A436
Conjugation
Unconjugated
Applications
WB; IHC; IF; IP
Field of Research
Epigenetics and Nuclear Signaling
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:500-1:1000; IHC 1:200-1:1000; IF 1:50; IP 1:25-1:50
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
183 kDa
Observed Molecular Weight
200 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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