Recombinant PDK2 Monoclonal Antibody
Product Specifications
Background
[Pyruvate dehydrogenase (acetyl-transferring) ] kinase isozyme 2 (PDK2) is a kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. PDK2 Mediates cellular responses to insulin and plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability.
Abbreviation
PDK2
UniProt
Q15119
Host
Rabbit
Reactivity
Human; Rat; Mouse
Immunogen
Recombinant human PDK2 fragment
Target
PDK; PDHK; Pyruvate dehydrogenase kinase isoform; Pyruvate dehydrogenase lipoamide kinase isozyme; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme; isozyme; PDK2; PDHK2; PDKII; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2; isozyme 2; mitochondrial; Pyruvate dehydrogenase kinase; Pyruvate dehydrogenase kinase isoform 2; Pyruvate dehydrogenase lipoamide kinase isozyme 2
Clonality
Monoclonal,Recombinant
Clone
A433
Conjugation
Unconjugated
Applications
WB
Field of Research
Signal Transduction; Cancer; Metabolism
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:1000-1:10000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Product MSDS
https://789.bio/eb/mtWbPs1g
Calculated Molecular Weight
46 kDa
Observed Molecular Weight
46 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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