Recombinant CD40 Monoclonal Antibody

The CD40 antigen is a 44-48 kDa type I integral membrane protein of the tumor necrosis factor receptor (TNFR) superfamily. This antigen is found on B cell lines, is strongly expressed by interdigitating cells (IDC), basal epithelial cells, and is also present on macrophages, some endothelial cells, and follicular dendritic cells. It is a well-known regulator of T cell immunity including in cancer. CD40-ligand, primarily expressed on activated T cells, interacts with CD40 on APCs resulting in a ‘licensed’ state.

CDW; B-cell surface antigen CD; Tumor necrosis factor receptor superfamily member; TNFRSF; CD40; Bp50; CDW40; TNFRSF5; p50; Tumor necrosis factor receptor superfamily member 5; B-cell surface antigen CD40; CD40L receptor; TNFRSF5; AI326936; B cell associated molecule CD40; B cell surface antigen CD40; B cell-associated molecule; CD 40; CD40 (protein) ; CD40 antigen; CD40 antigen (TNF receptor superfamily member 5) ; CD40 molecule; CD40 protein; CD40 type II isoform; GP39; HIGM1; IGM; IMD3; isoform CRA_a; member 5; MGC9013; Nerve growth factor receptor related B lymphocyte activation molecule; OTTHUMP00000031699; OTTHUMP00000031700; TBAM; T-BAM; TNF receptor superfamily member 5; TNR5; TRAP; Tumor necrosis factor receptor superfamily; Tumor necrosis factor receptor superfamily member 5 precursor