Recombinant TPX2 Monoclonal Antibody

Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules.Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. TPX2 is inactivated upon binding to importin-alpha .At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation.

FLS; HCA; TPX; HCTP; REPP; GD:C20orf; DIL; DIL2; p100; DIL-2; HCTP4; FLS353; HCA519; REPP86; C20orf1; C20orf2; GD:C20orf1; TPX2; Chromosome 20 Open Reading Frame 1; Differentially expressed in cancerous and noncancerous lung cells 2; Differentially expressed in cancerous and non-cancerous lung cells 2; Differentially expressed in lung cells; Differentially expressed in lung cells 2; DIL 2; HCA 519; HCTP 4; Hepatocellular carcinoma associated antigen 519; Hepatocellular carcinoma-associated antigen 519; Preferentially expressed in colorectal cancer; Protein fls353; REPP 86; Restricted expression proliferation associated protein 100; Restricted expression proliferation-associated protein 100; Targeting protein for Xklp2; TPX 2; TPX2 microtubule associated homolog; TPX2 microtubule associated protein homolog; TPX2 microtubule nucleation factor