Recombinant Thymidylate Synthase Monoclonal Antibody
Product Specifications
Background
Thymidylate synthase (TS) is a key enzyme in the synthesis of 2'-deoxythymidine-5'-monophosphate, an essential precursor for DNA biosynthesis. Thymine nucleotide synthase is a key enzyme in the de novo synthesis pathway of mitochondrial thymine. For this reason, it is a key target for cancer chemotherapy, and considered to be the main target of 5-fluorouric acid, 5-fluoro-2'-deoxyribonucleic acid and some folate compounds.
Abbreviation
Thymidylate Synthase
UniProt
P04818
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant human Thymidylate Synthase fragment
Target
HST; OK/SW-cl; TYMS; HST422; TMS; TS; thymidylate synthase; OK/SW-cl.29; HST422; thymidylate synthase; TMS; thymidylate synthetase
Clonality
Monoclonal,Recombinant
Clone
A377
Conjugation
Unconjugated
Applications
WB; IHC; IF; IP
Field of Research
Epigenetics and Nuclear Signaling; Metabolism
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:500-1:1000; IHC 1:100-1:1000; IF 1:50; IP 1:25-1:100
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
36 kDa
Observed Molecular Weight
34 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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