Recombinant PPM1A Monoclonal Antibody
Product Specifications
Background
Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.
Abbreviation
PPM1A
UniProt
P35813
Host
Rabbit
Reactivity
Human; Mouse
Immunogen
Recombinant human PPM1A fragment
Target
PPM1A; PP2C-ALPHA; PP2CA; PP2Calpha; Protein Phosphatase 1A; Protein Phosphatase 2C Isoform Alpha; Protein Phosphatase IA; PPPM1A
Clonality
Monoclonal,Recombinant
Clone
A336
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Signal Transduction
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:500-1:1000; IHC 1:50-1:100
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
42 kDa
Observed Molecular Weight
42 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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