Recombinant PI3 Kinase p85 alpha Monoclonal Antibody

Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement.

GRB; IMD; AGM; PIK3R; AGM7; GRB1; IMD36; p85; p85-ALPHA; PI3 Kinase p85 alpha; PIK3R1; p85 alpha; P85A; Phosphatidylinositol 3 kinase; Phosphatidylinositol 3 kinase associated p 85 alpha; Phosphatidylinositol 3 kinase regulatory 1; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; Phosphatidylinositol 3-kinase regulatory subunit alpha; Phosphoinositide 3 kinase; PI3 kinase p85 subunit alpha; PI3K; PI3K regulatory subunit alpha; PI3-kinase regulatory subunit alpha; PI3-kinase subunit p85-alpha; polypeptide 1 (p85 alpha) ; PtdIns 3 kinase p85 alpha; PtdIns-3-kinase regulatory subunit alpha; PtdIns-3-kinase regulatory subunit p85-alpha; regulatory subunit; regulatory subunit 1 (alpha)