Recombinant PD-L1 Monoclonal Antibody

PD-1 is an immunoinhibitory receptor expressed by activated T cells, B cells, and myeloid cells. Engagement of PD-1 by PD-L1 leads to the inhibition of T cell receptor–mediated lymphocyte proliferation and cytokine secretion. In addition, PD-1 signaling can inhibit at least suboptimal levels of CD28-mediated costimulation. PD-L1 is expressed by antigen-presenting cells, including human peripheral blood monocytes stimulated with interferong, and activated human and murine dendritic cells.

PDL; B7H; PD-L; PD1L; Programmed cell death 1 ligand; PDCD1L; PDCD1LG; B7-H; B7H1; PDL1; PD-L1; PDCD1L1; PDCD1LG1; CD274; B7-H1; B7 homolog 1; CD274 molecule; PDCD1 ligand 1; Programmed death ligand 1; PD1L1; Programmed cell death 1 ligand 1; PDL1; PD-L1; B7-H; B7H1; CD274 molecule; PDCD1L1; PDCD1LG1; B7 H; B7 H1; CD 274; CD274 antigen; MGC142294; MGC142296; OTTHUMP00000021029; PD L1; PDL 1; RGD1566211