Recombinant ARPC5/p16 ARC Monoclonal Antibody
Product Specifications
Background
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) . The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) .
Abbreviation
ARPC5/p16 ARC
UniProt
O15511
Host
Rabbit
Reactivity
Human; Rat; Mouse
Immunogen
Recombinant human ARPC5/p16 ARC fragment
Target
ARC; ARPC; dJ127C; ARPC5; ARC16; dJ127C7.3; p16-Arc
Clonality
Monoclonal,Recombinant
Clone
A319
Conjugation
Unconjugated
Applications
WB; IHC; IF; FCM
Field of Research
Signal Transduction
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000; IHC 1:50-1:100; IF 1:50; FCM 1:50
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
16 kDa
Observed Molecular Weight
16 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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