Recombinant CDKN2A/p14ARF Monoclonal Antibody
Product Specifications
Background
Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression.
Abbreviation
CDKN2A/p14ARF
UniProt
Q8N726
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant human CDKN2A/p14ARF fragment
Target
CDKN; CDKN2; MLM; CDKN2A
Clonality
Monoclonal,Recombinant
Clone
A318
Conjugation
Unconjugated
Applications
WB; IHC; IF; IP
Field of Research
Cell Biology; Epigenetics and Nuclear Signaling; Cancer
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:50; IP 1:50-1:100
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
14 kDa
Observed Molecular Weight
14 kDa
Isotype
IgG, κ
Available Sizes
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