Recombinant MUC1 Monoclonal Antibody

The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.

MAM; CA 15; MUC; ADMCKD; ADMCKD1; CA 15-3; CD227; EMA; H23AG; KL-6; MAM6; MCD; MCKD; MCKD1; MUC-1; MUC-1/SEC; MUC-1/X; MUC1/ZD; PEM; PEMT; PUM; MUC1; CA15-3; mucin-1; CA15 3; CA153; Episialin; Carcinoma associated mucin; MUC 1; MUC1 beta; MUC1 CT; MUC1 NT; Mucin 1; Peanut reactive urinary mucin; Polymorphic epithelial mucin; Tumor associated mucin; MUC1/CA15-3 C-terminal; EMA; mucin 1; Breast carcinoma-associated antigen DF3; Cancer antigen 15-3; Carcinoma-associated mucin; Krebs von den Lungen-6; Peanut-reactive urinary mucin; Tumor-associated epithelial membrane antigen; Tumor-associated mucin