Recombinant LysRS Monoclonal Antibody
Product Specifications
Background
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity. Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA3 (Lys), the primer for reverse transcription initiation.
Abbreviation
LysRS
UniProt
Q15046
Host
Rabbit
Reactivity
Human; Rat; Mouse
Immunogen
Recombinant human LysRS fragment
Target
DFNB; KIAA; KARS; CMTRIB; DFNB89; KARS1; KARS2; KRS; EC 6.1.1.6; KARS 1; KARS 2; Lysine tRNA ligase; Lysine--tRNA ligase; LysRS; Lysyl-tRNA synthetase; SYK; KIAA0070
Clonality
Monoclonal,Recombinant
Clone
A291
Conjugation
Unconjugated
Applications
WB; IHC; IF; IP
Field of Research
Epigenetics and Nuclear Signaling
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:500-1:1000; IHC 1:50-1:100; IF 1:50; IP 1:25-1:50
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
75 kDa
Observed Molecular Weight
75 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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