Recombinant iNOS Monoclonal Antibody
Product Specifications
Background
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8.
Abbreviation
INOS
UniProt
P29477
Host
Rabbit
Reactivity
Human; Mouse
Immunogen
Recombinant human iNOS fragment
Target
NOS; HEP-NOS; I-NOS; NOS2A; inducible; Inos; MAC-NOS; Inosl; Nitric oxide synthase; NOS type II; Nos2
Clonality
Monoclonal,Recombinant
Clone
A267
Conjugation
Unconjugated
Applications
IHC
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
IHC 1:50-1:100
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG, κ
Available Sizes
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