Recombinant Human IgD Monoclonal Antibody
Product Specifications
Background
IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD.
Abbreviation
Human IgD
UniProt
P01880
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant human Human IgD fragment
Target
IGHD
Clonality
Monoclonal,Recombinant
Clone
A258
Conjugation
Unconjugated
Applications
WB; IHC; IF
Field of Research
Immunology; Stem Cells
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:500-1:1000; IHC 1:50; IF 1:50
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Product MSDS
https://789.bio/eb/veNWH4lE
Calculated Molecular Weight
42 kDa
Observed Molecular Weight
75 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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