Recombinant c-erbB-3/HER-3 Monoclonal Antibody
Product Specifications
Background
Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5) . Involved in the regulation of myeloid cell differentiation.
Abbreviation
C-erbB-3/HER-3
UniProt
P21860
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant human c-erbB-3/HER-3 fragment
Target
HER; LCCS; Proto-oncogene-like protein c-ErbB; Tyrosine kinase-type cell surface receptor HER; MDA-BF; p180-ErbB; p45-sErbB; p85-sErbB; ERBB3; ErbB-3; HER3; LCCS2; MDA-BF-1; c-erbB-3; c-erbB3; erbB3-S; p180-ErbB3; p45-sErbB3; p85-sErbB3; Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3; EEBB3
Clonality
Monoclonal,Recombinant
Clone
A215
Conjugation
Unconjugated
Applications
IHC
Field of Research
Signal Transduction; Cancer
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
IHC 1:100-1:1000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG, κ
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