Recombinant DYNLL1 Monoclonal Antibody

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.

DNCL; hdlc; Dynein Light Chain LC8-Type; DYNLL; DNCLC; DLC; DYNLL1; DLC1; DLC8; DNCL1; DNCLC1; LC8; LC8a; PIN; hdlc1;8 kDa Dynein Light Chain; Dynein Light Chain 1 Cytoplasmic; Dynein Light Chain LC8-Type 1; Protein Inhibitor of Neuronal Nitric Oxide Synthase;8kDLC; cytoplasmic; Cytoplasmic dynein light polypeptide; DYL1; Dynein; Dynein light chain 1; Dynein light chain LC8 type 1; HDLC1; LC8-type 1; light chain; light chain 1; light polypeptide 1; MGC126137; MGC126138; MGC72986; Protein inhibitor of neuronal NOS