Recombinant Phospho-Cyclin D1 (Thr286) Monoclonal Antibody

Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.

Cyl; PRAD; U21B; CCND; B cell leukemia; G1/S specific cyclin D; Cyclin D; BCL; BCL1; D11S287E; PRAD1; U21B31; CCND1; Cyclin D1; B cell leukemia 1; BCL 1; Cd1; Cyl 1; G1/S specific cyclin D1; BCL1; D11S287E; PRAD1; U21B31; CCND1; Cyclin D1; cyclin D1