Recombinant CSF-1R Monoclonal Antibody

Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion.

FIM; CSF1R; C-FMS; CD115; CSF-1R; CSFR; FIM2; FMS; HDLS; M-CSF-R; BANDDOS; CSF-1 receptor; CSF-1-R; Macrophage colony-stimulating factor 1 receptor; MCSF Receptor; Proto-oncogene c-Fms; M-CSFR; c-fms; CSF-1R; FMS; C FMS; CD 115; CD115 antigen; CFMS; Colony stimulating factor 1 receptor; Colony stimulating factor I receptor; CSF 1 R; CSF 1R; CSF1 R; EC 2.7.10.1; FIM 2; FMS proto oncogene; FMS protooncogene; formerly; Macrophage colony stimulating factor 1 receptor; Macrophage colony stimulating factor I receptor; McDonough feline sarcoma viral (v fms) oncogene homolog; M-CSF Receptor; MCSF Receptor; MCSFR; Oncogen FMS; V-FMS McDonough feline sarcoma viral oncogen homolog