Recombinant CDK8 Monoclonal Antibody
Product Specifications
Background
Cyclin-dependent kinase 8 (CDK8) is a cell cycle regulator, which can activate cyclin C, act in the G1/S phase, and regulate the normal cell cycle. CDK8 together with Cyclin, Med12 and Med13 form an intermediary complex, which is widely involved in the transmission of information between RNA polymerase II and gene-specific transcription factors, which can activate and inhibit transcription. In addition, CDK8 can activate a variety of signal transduction pathways such as Wnt/β-catenin and Notch, thereby inducing the occurrence and metastasis of malignant tumors such as rectal cancer and melanoma. Recent studies have found that blocking the activity of CDK8 gene can greatly reduce the glucose utilization rate of cancer cells.
Abbreviation
CDK8
UniProt
P49336
Host
Rabbit
Reactivity
Human; Mouse
Immunogen
Recombinant human CDk8 fragment
Target
CDK; CDK8; K35; Cell division protein kinase 8
Clonality
Monoclonal,Recombinant
Clone
A183
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Cell Biology; Epigenetics and Nuclear Signaling
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:500-1:1000; IHC 1:50-1:100
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Product MSDS
https://789.bio/eb/s9M8Xdsk
Calculated Molecular Weight
53 kDa
Observed Molecular Weight
53 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
50805121 3 x 1.0μg DNA
ZDHHC5 CRISPRa sgRNA lentivector (set of three targets)(Human)
Ask
View Details