Recombinant CD79a Monoclonal Antibody
Product Specifications
Background
Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.
Abbreviation
CD79a
UniProt
P11912
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant human CD79a fragment
Target
CD79A; IGA; MB-1; CD79a molecule; CD79A antigen; MB1; MB1; Ig&alpha
Clonality
Monoclonal,Recombinant
Clone
A181
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Immunology; Cancer; Stem Cells
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:1000-1:5000; IHC 1:200-1:1000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
25 kDa
Observed Molecular Weight
44-48 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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