Recombinant CD33 Monoclonal Antibody
Product Specifications
Background
Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state. Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK. These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules.
Abbreviation
CD33
UniProt
P20138
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant human CD33 fragment
Target
CD33; SIGLEC-3; SIGLEC3; p67; CD33 molecule; gp67; Myeloid cell surface antigen CD33; Sialic acid-binding Ig-like lectin 3; Siglec-3; CD33 molecule; p67; SIGLEC3
Clonality
Monoclonal,Recombinant
Clone
A170
Conjugation
Unconjugated
Applications
IHC
Field of Research
Immunology; Stem Cells
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
IHC 1:200-1:1000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG, κ
Available Sizes
Curated Selection
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